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Effects of Antidepressant Treatments on Platelet Tritiated Imipramine Binding in Major Depressive Disorder
Anna Wagner, PhD, MD;
Anna Åberg-Wistedt, MD;
Marie Åsberg, MD;
Leif Bertilsson, PhD;
Björn Mårtensson, MD;
Dolores Montero, MD
Arch Gen Psychiatry. 1987;44(10):870-877.
Abstract
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• The effects of four antidepressant treatments on platelet tritiated imipramine binding have been studied in 51 hospitalized patients with severe major depressive disorder. There was an increase in maximum binding (Bmax) during the first week of treatment with antidepressants and electroconvulsive therapy, which was further magnified after three weeks' treatment with the serotonin uptake blockers alaproclate and zimeldine hydrochloride, but the Bmax values returned to baseline levels with nortriptyline hydrochloride and electroconvulsive therapy. The equilibrium dissociation affinity constant (Kd) did not change with any of the treatments. On reexamination one or two years after admission to the study, Bmax had not reached control values in clinically recovered, drug-free patients. Low pretreatment Bmax was associated with delusions during illness and with a poor long-term clinical outcome. There was no correlation between binding parameters and monoamine metabolite concentrations in the cerebrospinal fluid, either before or during treatment.
Author Affiliations
From the Department of Clinical Pharmacology, Karolinska Institute and Huddinge Hospital, Huddinge (Drs Wägner, Bertilsson, and Montero); Department of Psychiatry, Karolinska Institute, Danderyd Hospital, Danderyd (Dr Åberg-Wistedt); and Department of Psychiatry and Psychology, Karolinska Institute, Karolinska Hospital, Stockholm (Drs Wagner, Åsberg, and Mårtensson), Sweden.
Footnotes
Accepted for publication March 5, 1987.
Reprint requests to Department of Psychiatry and Psychology, Karolinska Hospital, 104 01 Stockholm, Sweden (Dr Wagner).
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