 |
|
Recovery From Major DepressionA 10-Year Prospective Follow-up Across Multiple Episodes
David A. Solomon, MD;
Martin B. Keller, MD;
Andrew C. Leon, PhD;
Timothy I. Mueller, MD;
M. Tracie Shea, PhD;
Meredith Warshaw, MSS, MA;
Jack D. Maser, PhD;
William Coryell, MD;
Jean Endicott, PhD
Arch Gen Psychiatry. 1997;54(11):1001-1006.
Abstract
| |
Background
Major depressive disorder is often marked by repeated episodes of depression. We describe recovery from major depession across multiple mood episodes in patients with unipolar major depression at intake and examine the association of sociodemographic and clinical variables with duration of illness.
Methods
A cohort of 258 subjects treated for unipolar major depressive disorder was followed up prospectively for 10 years as part of the Collaborative Depression Study, a multicenter naturalistic study of the mood disorders. Diagnoses were made according to the Research Diagnostic Criteria, and the course of illness was assessed with the Longitudinal Interval Follow-up Evaluation. Survival analyses were used to calculate the duration of illness for the first 5 recurrent mood episodes after recovery from the index episode.
Results
Diagnosis remained unipolar major depressive disorder for 235 subjects (91%). The median duration of illness was 22 weeks for the first recurrent mood episode, 20 weeks for the second, 21 weeks for the third, and 19 weeks for the fourth and fifth recurrent mood episodes; the 95% confidence intervals were highly consistent. From one episode to the next, the proportion of subjects who recovered by any one time point was similar. For subjects with 2 or more recoveries, the consistency of duration of illness from one recovery to the next was low to moderate. None of the sociodemographic or clinical variables consistently predicted duration of illness.
Conclusion
In this sample of patients treated at tertiary care centers for major depressive disorder, the duration of recurrent mood episodes was relatively uniform and averaged approximately 20 weeks.
Author Affiliations
From the Department of Psychiatry and Human Behavior, Brown University, Providence, RI (Drs Solomon, Keller, Mueller, and Shea and Ms Warshaw); Department of Psychiatry, Cornell University, New York, NY (Dr Leon); National Institute of Mental Health, Washington, DC (Dr Maser); Department of Psychiatry, University of Iowa College of Medicine, Iowa City (Dr Coryell); and Department of Research and Training, New York State Psychiatric Institute, New York, NY (Dr Endicott). The names of the investigators participating in the National Institute of Mental Health—Collaborative Program on the Psychobiology of Depression (Collaborative Depression Study) are listed at the end of this article.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Population-Based Study of First Onset and Chronicity in Major Depressive Disorder
Eaton et al.
Arch Gen Psychiatry 2008;65:513-520.
ABSTRACT
| FULL TEXT
Severity of depressive episodes during the course of depressive disorder
Kessing
Br. J. Psychiatry 2008;192:290-293.
ABSTRACT
| FULL TEXT
Course of Depressive Symptoms After Myocardial Infarction and Cardiac Prognosis: A Latent Class Analysis
Kaptein et al.
Psychosom. Med. 2006;68:662-668.
ABSTRACT
| FULL TEXT
Recovery from Depression: A Two-Year Follow-Up Study of General Population Subjects
Viinamaki et al.
Int J Soc Psychiatry 2006;52:19-28.
ABSTRACT
Prognosis of Depression in Old Age Compared to Middle Age: A Systematic Review of Comparative Studies
Mitchell and Subramaniam
Am. J. Psychiatry 2005;162:1588-1601.
ABSTRACT
| FULL TEXT
Reducing the global burden of depression: Population-level analysis of intervention cost-effectiveness in 14 world regions
Chisholm et al.
Br. J. Psychiatry 2004;184:393-403.
ABSTRACT
| FULL TEXT
Pharmacotherapy Plus Psychotherapy for Treatment of Depression in Active Injection Drug Users
Stein et al.
Arch Gen Psychiatry 2004;61:152-159.
ABSTRACT
| FULL TEXT
Past, Present, and Future Directions for Defining Optimal Treatment Outcome in Depression: Remission and Beyond
Keller
JAMA 2003;289:3152-3160.
ABSTRACT
| FULL TEXT
Duration of major depressive episodes in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS)
SPIJKER et al.
Br. J. Psychiatry 2002;181:208-213.
ABSTRACT
| FULL TEXT
Integrating Outcomes Research Into Clinical Practice
Posternak et al.
Psychiatr. Serv. 2002;53:335-336.
ABSTRACT
| FULL TEXT
Can Recovery From Depression Be Achieved?
Shelton and Tomarken
Psychiatr. Serv. 2001;52:1469-1478.
ABSTRACT
| FULL TEXT
Principal and Additional DSM-IV Disorders for Which Outpatients Seek Treatment
Zimmerman and Mattia
Psychiatr. Serv. 2000;51:1299-1304.
ABSTRACT
| FULL TEXT
General Psychiatry
Barchas and Marzuk
JAMA 1998;280:961-962.
FULL TEXT
The Clinical Course of Unipolar Major Depressive Disorders
Judd
Arch Gen Psychiatry 1997;54:989-991.
ABSTRACT
|
