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Prolongation of Brainstem Auditory-Evoked Responses in Autistic Probands and Their Unaffected Relatives
Michel Maziade, MD, FRCP(C);
Chantal Mérette, PhD;
Mireille Cayer, MSc;
Marc-André Roy, MD, FRCP(C);
Peter Szatmari, MD;
Robert Côté, PhD;
Jacques Thivierge, MD, FRCP(C)
Arch Gen Psychiatry. 2000;57:1077-1083.
Background Brain function, as indexed by brain electrical activity, is heritable in humans, and it may be impaired in autism. Autism also has strong genetic determinants, and like all major psychiatric disorders, its complex clinical phenotype renders genetic studies difficult. Innovative strategies focused on alternative biological phenotypes are needed.
Methods The early brain auditory-evoked response was assessed in 73 autistic probands and 251 relatives who were compared with 521 normal controls.
Results We first confirmed in the autistic probands the presence of a slowing in nerve conduction in the auditory system as expressed by the prolongation of early brain auditory-evoked response under the form of I-III interpeak latencies (IPLs). Furthermore, we observed the same I-III IPL prolongation in the unaffected first degree relatives of the autistic probands compared with controls. Despite clear evidence of a coaggregation of autism and I-III IPL prolongation in families, the IPLs did not seem to be the sole liability factor for autism as suggested by the observation of 52% of families in which the autistic proband and relatives showed normal IPLs.
Conclusion A prolongation of the early brain auditory-evoked response IPLs may be a marker for one of several deficits underlying autism and deserves further analysis as a potential alternative phenotype for the disorder.
From the Centre de recherche Université Laval Robert-Giffard, Hôtel-Dieu du Sacré-Coeur de Jésus, Québec, Sainte-Foy, Québec (Drs Maziade, Mérette, Roy, Thivierge and Mrs Cayer); Department of Psychiatry, the Centre for Studies of Children at Risk, Chedoke-McMaster Hospitals, Hamilton, Ontario (Dr Szatmari); and the Département de mathématiques et statistique, Faculté des sciences et de génie, Université Laval, Sainte-Foy (Dr Côté).
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