 |
|
Prepulse Inhibition of the Startle Response in Men With Schizophrenia
Effects of Age of Onset of Illness, Symptoms, and Medication
Veena Kumari, MA, PHD;
William Soni, MB, BS, MSc;
Vallakalil M. Mathew, MB, BS, MRCPsych;
Tonmoy Sharma, MSc, MRCPsych
Arch Gen Psychiatry. 2000;57:609-614.
Background Prepulse inhibition of the startle reflex response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. This effect represents an operational index of sensorimotor gating and is found to be deficient in schizophrenia. Prepulse inhibition deficits in schizophrenia seem to be partially normalized by typical antipsychotics and more fully by some atypical antipsychotics. Early onset of schizophrenia, particularly in men, has been associated with abnormal brain maturation, profound neuropsychological deficits, and less responsiveness to antipsychotic medication. We evaluated the effects of the age of onset of illness, current positive and negative symptoms, and the type of medication (typical vs atypical) on prepulse inhibition of the startle response in schizophrenia.
Methods Thirty-eight male schizophrenic patients and 20 healthy male controls underwent testing for prepulse inhibition of the acoustic startle response.
Results Earlier onset of illness was associated with reduced prepulse inhibition, while adult onset of illness was not. No significant relationships occurred between current symptoms and prepulse inhibition. Patients given typical, but not atypical, antipsychotics exhibited less prepulse inhibition compared with healthy controls.
Conclusion Early onset of illness is associated with profound deficits in prepulse inhibition of the startle response in men with schizophrenia.
From the Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, University of London, London, England.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Impaired Prepulse Inhibition and Prepulse-Elicited Reactivity but Intact Reflex Circuit Excitability in Unmedicated Schizophrenia Patients: a Comparison With Healthy Subjects and Medicated Schizophrenia Patients
Csomor et al.
Schizophr Bull 2009;35:244-255.
ABSTRACT
| FULL TEXT
Two Quantitative Trait Loci for Prepulse Inhibition of Startle Identified on Mouse Chromosome 16 Using Chromosome Substitution Strains
Petryshen et al.
Genetics 2005;171:1895-1904.
ABSTRACT
| FULL TEXT
Predicting Drug Efficacy for Cognitive Deficits in Schizophrenia
Hagan and Jones
Schizophr Bull 2005;31:830-853.
ABSTRACT
| FULL TEXT
Sex effects in prepulse inhibition and facilitation of the acoustic startle response: implications for pharmacological and treatment studies
Aasen et al.
J Psychopharmacol 2005;19:39-45.
ABSTRACT
Increasing Dopaminergic Activity: Effects of L-Dopa and Bromocriptine on Human Sensory Gating
Oranje et al.
J Psychopharmacol 2004;18:388-394.
ABSTRACT
Effects of Amisulpride, Risperidone and Chlorpromazine on Auditory and Visual Latent Inhibition, Prepulse Inhibition, Executive Function and Eye Movements in Healthy Volunteers
Barrett et al.
J Psychopharmacol 2004;18:156-172.
ABSTRACT
Information Processing Deficits in Acutely Psychotic Schizophrenia Patients Medicated and Unmedicated at the Time of Admission
Perry et al.
Am. J. Psychiatry 2002;159:1375-1381.
ABSTRACT
| FULL TEXT
Brain anatomy and sensorimotor gating in Asperger's syndrome
McAlonan et al.
Brain 2002;125:1594-1606.
ABSTRACT
| FULL TEXT
Neurotensin and Dopamine Interactions
Binder et al.
Pharmacol. Rev. 2001;53:453-486.
ABSTRACT
| FULL TEXT
|
