 |
|
Incidence of Schizophrenia in a Nationwide Cohort of Patients With Type 1 Diabetes Mellitus
Hannu Juvonen, MD;
Antti Reunanen, MD, PhD;
Jari Haukka, PhD;
Maria Muhonen, MD;
Jaana Suvisaari, MD, PhD;
Ritva Arajärvi, MD, PhD;
Timo Partonen, MD, PhD;
Jouko Lönnqvist, MD, PhD
Arch Gen Psychiatry. 2007;64(8):894-899.
Context Patients with schizophrenia have an increased risk of type 2 diabetes mellitus. However, very few studies have dealt with the association of type 1 diabetes and schizophrenia. Preliminary evidence points to a possible inverse association.
Objective To investigate the incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes born in 1950 through 1959 in Finland.
Design A cohort study of individuals born in 1950 through 1959 with a follow-up of 1969 through 1991.
Setting Finland.
Patients All individuals born in 1950 through 1959 with type 1 diabetes were identified through nationwide registers. The incidence of schizophrenia until 1992 among the total 1950-1959 cohort and in individuals with type 1 diabetes was calculated using information from 3 health care registers.
Main Outcome Measure Incidence of schizophrenia.
Results The incidence of schizophrenia was 0.21 per 10 000 person-years in the group with type 1 diabetes and 0.56 per 10 000 person-years in the group without type 1 diabetes (P < .001).
Conclusion The incidence of schizophrenia is decreased in patients with type 1 diabetes.
Author Affiliations: Departments of Mental Health and Alcohol Research (Drs Juvonen, Haukka, Muhonen, Suvisaari, Arajärvi, Partonen, and Lönnqvist) and Health and Functional Capacity (Dr Reunanen), National Public Health Institute, Helsinki, Finland.
RELATED LETTER
Diabetes Mellitus and Schizophrenia
Preben Bo Mortensen and William W. Eaton
Arch Gen Psychiatry. 2008;65(2):237-238.
EXTRACT
| FULL TEXT
|
