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Hippocampal atrophy has previously been reported in both postmortem and magnetic resonance imaging (MRI) studies in patients with schizophrenia compared with normal controls.^1-3 The neuroanatomic specificity of this finding for schizophrenia, however, remains to be determined. We have recently completed a small MRI study that suggests the following: (1) that this abnormality occurs in patients with schizophrenia but not in patients with bipolar disorder; and (2) that the amygdala may be enlarged in patients with bipolar disorder compared with both patients with schizophrenia and healthy control subjects. Herein we describe our preliminary findings.

Subjects and Methods

Patients attending an outpatient mental health clinic at the West Los Angeles Veterans Affairs Medical Center, Los Angeles, Calif, who met Structured Clinical Interview for DSM-III⁴ (SCID) criteria for schizophrenia or bipolar disorder with no other Axis I comorbidity were included in the study. A healthy comparison population was recruited from newspaper advertisements and fliers placed in . . . [Full Text of this Article]

Results

Comment

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