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Arch Gen Psychiatry. 1999;56:556.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

SHOULD a reader of my article¹ be tempted to conclude that genetics will soon solve psychiatry's most serious problems, the comments of Goldman² and Kendler³ will serve to bring this dreamer back to earth. Both major contributors to psychiatric genetics, Goldman and Kendler have firsthand knowledge of the many challenges that lie ahead. They are right to remind us that the hunt for gene variants that influence susceptibility to mental illness is only a prelude to "a further agenda"² and that we are just approaching the base camp of the "big mountain."³

Nevertheless, though emphasizing caveats, Goldman and Kendler do agree that we are already in a position to vigorously hunt for the specific gene variants that influence vulnerability to the major psychiatric disorders. To me, this is a very big deal; it was not long ago that even this limited goal seemed completely out of reach. Although Kendler is . . . [Full Text of this Article]

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