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Peeking Through the Door to the 21st Century
Ellen Frank, PhD;
David J. Kupfer, MD
Arch Gen Psychiatry. 2000;57:83-85.
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INTRODUCTION
As we stand at the door to the 21st century, psychiatry, supported by the incredibly rapid pace of discovery in the neurosciences, seems poised to address questions that could not even have been imagined just 50 or 100 years ago. We outline 6 such questions. These questions have particular appeal to us because they draw concurrently on evolving science in the neurobiological and psychosocial arenas and because they seem especially ripe for exploration at the present time.
HOW DOES LIFE EXPERIENCE ALTER GENE EXPRESSION IN VULNERABLE INDIVIDUALS?
We have substantial evidence from genetic pedigree studies and from family studies1 of monozygotic twins that not everyone carrying the genetic vulnerability to a disorder necessarily expresses that disorder. We also have substantial evidence that stressful life events and ongoing long-term difficulties are critical in the timing of onset of first and subsequent episodes of even the most "genetic" of psychiatric disorders.2-4 A key question then . . . [Full Text of this Article]
WHAT ARE THE NEUROBIOLOGICAL EFFECTS OF PSYCHOTHERAPY?
HOW DOES TRAUMA LEAD TO SUCH A WIDE AND COMPLEX RANGE OF SYMPTOMS?
CAN WE DEVELOP ADVERSE EFFECT–FREE PHARMACOTHERAPIES?
WHAT IS THE CONNECTION BETWEEN VARIOUS PHYSICAL ILLNESSES AND MOOD AND ANXIETY REGULATION?
HOW DOES THE AGING PROCESS AFFECT DISORDER EXPRESSION AND TREATMENT?
From the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pa.
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