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The article by Velakoulis et al¹ reported the important finding of hippocampal volume reduction in first-episode schizophrenia and interpreted it as evidence in support of a neurodevelopmental model of this disorder. The authors stated that "no [previous] studies have examined the specificity of this finding to first-episode schizophrenia, compared with first-episode affective psychosis."¹(p133) Probably because their article was in press (it was accepted for publication on October 2, 1998), Velakoulis and coworkers did not cite our report² in the October 1998 issue of the American Journal of Psychiatry, which, to our knowledge, was the first published report of lack of specificity of hippocampal volume reduction in first-episode schizophrenia relative to first-episode affective psychosis. Our study used a spoiled gradient-recalled acquisition protocol, resulting in 124 contiguous 1.5-mm coronal slices, to evaluate the hippocampus in 17 patients with first-episode schizophrenic psychosis compared with 16 first-episode affective psychosis patients and 18 . . . [Full Text of this Article]

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