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Are 3 Fatty Acids Beneficial in Depression but Not Mania?

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In their innovative preliminary trial, Stoll et al¹ concluded that 3 fatty acids were well tolerated and improved the short-term course of illness in patients with bipolar disorder. Although only 120 days in the blind phase, this study was reasonably well-designed. The primary outcome measure was the length of time to complete the blind phase of the study without any treatment-emergent mood episodes, but the results as shown in Table 2¹ also showed that all of the "noncompleted" cases (3 of 14 cases) in the 3 group developed a manic episode (mania, hypomania, and worsening of mixed state), whereas the depressive symptoms of all of the noncompleted cases (10 of 16 cases), except 1 in the placebo group, worsened! The aforementioned observation might suggest the hypothesis that 3 fatty acids could prevent depression but not mania among the bipolar patients. To test this hypothesis, future research should design a way . . . [Full Text of this Article]

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