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The 3 domains (3D) model of psychopathology in schizophrenia hypothesizes that positive, negative, and disorganized symptoms form mutually independent structures when symptom ratings are factor-analyzed. Using 6-category response data from the DSM-IV Field Trial for Schizophrenia and Related Disorders, Ratakonda et al¹ have argued that this structure is generalizable to other psychotic disorders. As evidence, they presented a descriptive comparison of Varimax-rotated solutions (Varimax Information Systems Inc, Saskatoon, Saskatchewan) from separate principal components analyses of a subgroup of patients (n = 221) diagnosed as having DSM-III-R schizophrenia and a second heterogeneous subgroup (n = 189) composed of patients with other DSM-III-R psychotic disorders.

However, when we fitted confirmatory factor analysis² (CFA) models to the same Field Trial data (with listwise deletion for missing observations), we found no support for either the 3D model or its inferred generalizability to other disorders.

The least restrictive CFA model we fitted that tests the . . . [Full Text of this Article]

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