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The studies by Pope et al,¹ Rabkin et al,² and Tuiten et al,³ and the commentary by Yates⁴ on the risks and benefits of the use of testosterone in psychiatry, emphasize the relevance of androgens in the regulation of mood and behavior in humans. We wish to add a caveat to the interpretation of the Rabkin article, though. Although Rabkin et al reported the efficacy of testosterone (T) in treating depressed mood, there were no significant effects of T observed on the affective symptoms subscale of the Hamilton Rating Scale scores. Significance was identified, however, by the Somatic Symptoms Subscale in both the total group of men and the subgroup of men meeting criteria for depression. Rabkin's study, then, like that of Grinspoon et al,⁵ suggests that the ostensible effects of T on mood are secondary to its remediation of somatic symptoms such as fatigue, which is probably mediated by . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Testosterone Gel Supplementation for Men With Refractory Depression: A Randomized, Placebo-Controlled Trial
Pope et al.
Am. J. Psychiatry 2003;160:105-111.
ABSTRACT | FULL TEXT