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Sex and Psychopharmacology
Is Natural Estrogen a Psychotropic Drug in Women?
Arch Gen Psychiatry. 2001;58:537-538.
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ALTHOUGH it has been long recognized that estrogen affects mood, it
is still not clear what role estrogen may play in the management of major
depressive disorder.1, 2, 3, 4
This is startling, given the known link of estrogen to the increased incidence
of major depressive disorder in women across their life cycles.1, 2, 3, 4, 5
Furthermore, 70% of people taking antidepressants are women, and women make
90% of all health care decisions,6 yet there
are precious few studies examining the use of estrogen as an antidepressant,
or as an adjunct to antidepressant treatment of major depressive disorder.1, 2, 3, 4
The well-designed studies that do exist have been conducted mostly in
women experiencing mood fluctuations associated with the normal female life
cycle or with premenstrually linked mood disorders rather than in women with
major depressive disorder.1, 2, 3, 4
Furthermore, there have been hundreds of studies of dozens of new antidepressants
in thousands of women with major depressive disorder during the . . . [Full Text of this Article] ESTRADIOL AS AN ANTIDEPRESSANT: A NEW CONSIDERATION
HOW COULD ESTROGEN EXERT ANTIDEPRESSANT ACTIONS?
A PORTFOLIO OF POTENTIAL THERAPEUTIC ESTROGENS
A FORK IN THE ROAD: ESTROGEN,
ANTIDEPRESSANTS, OR BOTH?
RELATED ARTICLE
Efficacy of Estradiol for the Treatment of Depressive Disorders in Perimenopausal Women: A Double-blind, Randomized, Placebo-Controlled Trial
Cláudio de Novaes Soares, Osvaldo P. Almeida, Hadine Joffe, and Lee S. Cohen
Arch Gen Psychiatry. 2001;58(6):529-534.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Estrogen for Depression in Menopausal Women
JWatch General 2001;2001:6-6.
FULL TEXT
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