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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In the December 2000 issue of the ARCHIVES, Young et al¹ published an excellent article on alterations of the hypothalamic-pituitary-ovarian axis in depressed women, with a follow-up commentary by Halbreich.² In their article, Young and colleagues described decreased levels of circulating estradiol in the follicular phase of women with depression. They also report normal frequency and amplitude of the pulsatile release of luteinizing hormone (LH).

This article represents a new and important area of psychoendocrinology. Although there is a growing literature describing the pulsatile release of pituitary hormones in healthy women, this area remains in its infancy in the psychiatric literature. As pointed out by both Young et al¹ and Halbreich,² a single peripheral blood assay, or even a stimulation test, cannot find differences in pulsatile release.

We have recently completed a study of LH release in woman with depression.³ Using methods similar to those used by Young and coauthors, . . . [Full Text of this Article]