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The Role of Dopamine in the Pathophysiology of Depression
Boadie W. Dunlop, MD;
Charles B. Nemeroff, MD, PhD
Arch Gen Psychiatry. 2007;64(3):327-337.
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INTRODUCTION
Multiple sources of evidence support a role for diminished dopaminergic neurotransmission in major depression. The physiological alterations underlying reduced dopamine (DA) signaling could result from either diminished DA release from presynaptic neurons or impaired signal transduction, either due to changes in receptor number or function and/or altered intracellular signal processing. There are data supporting each of these mechanisms, although interpretation of previous research is confounded by issues around study population, medication status, and technological limitations. In some patients with depression, DA-related disturbances improve by treatment with antidepressants, presumably by acting on serotonergic or noradrenergic circuits, which then affect DA function. However, most antidepressant treatments do not directly enhance DA neurotransmission, which may contribute to residual symptoms, including impaired motivation, concentration, and pleasure. Animal models of major depression show considerable responsiveness to manipulations of DA neurotransmission. Several studies, including postmortem investigations, particularly . . . [Full Text of this Article]
DOPAMINERGIC PATHWAYS IN THE CENTRAL NERVOUS SYSTEM
DOPAMINE SYNTHESIS AND SIGNALING
ANIMAL MODELS OF DOPAMINE FUNCTION IN DEPRESSION
HUMAN GENETIC AND NEUROCHEMICAL STUDIES
DISTURBED REWARD SYSTEM FUNCTION IN DEPRESSION
POSTMORTEM FINDINGS
NEUROIMAGING FINDINGS
CLINICAL THERAPEUTICS
SEROTONIN-DOPAMINE INTERACTION
CONCLUSIONS
AUTHOR INFORMATION
Author Affiliations: Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Ga.
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