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Season as a Possible Confounding Factor in Reduced Brain Serotonin Turnover Following Selective Serotonin Reuptake Inhibitor Therapy—Reply
David A. Barton, FRANZP;
Murray D. Esler, MBBS, PhD;
Gavin W. Lambert, PhD
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In reply
Dr Papadopoulos raises some interesting and pertinent points. In our study, we did not take into account an individual's history of exposure to sunlight.1 Whether our depressed cohort was less exposed to sunlight compared with healthy subjects because of limited outdoor activities remains problematic. If so, this might be expected to lower their brain serotonin turnover.2
In the majority of patients (n = 6), the initial investigation was performed in spring with follow-up in summer; in 3 patients, the pattern was autumn/winter; and in the remaining patient, initial testing was in winter with the posttreatment investigation in spring. Sunlight duration pretreatment and posttreatment was not identical (mean [SD], 5.9 [3.5] hours/day vs 7.7 [3.7] hours/day; P = .26). Given this pattern of testing, and that we,2 and others,3-5 have previously demonstrated a positive interaction between brain serotonin, season, . . . [Full Text of this Article]
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RELATED ARTICLE
Elevated Brain Serotonin Turnover in Patients With Depression: Effect of Genotype and Therapy
David A. Barton, Murray D. Esler, Tye Dawood, Elisabeth A. Lambert, Deepak Haikerwal, Celia Brenchley, Florentia Socratous, Jacqueline Hastings, Ling Guo, Glen Wiesner, David M. Kaye, Richard Bayles, Markus P. Schlaich, and Gavin W. Lambert
Arch Gen Psychiatry. 2008;65(1):38-46.
ABSTRACT
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RELATED LETTER
Season as a Possible Confounding Factor in Reduced Brain Serotonin Turnover Following Selective Serotonin Reuptake Inhibitor Therapy
Fotios C. Papadopoulos
Arch Gen Psychiatry. 2008;65(10):1224-1225.
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