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Bernard J. Carroll, MBBS, PhD

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In "Influence of Child Abuse on Adult Depression: Moderation by the Corticotropin-Releasing Hormone Receptor Gene,"¹ Bradley et al studied 2 independent samples to test for associations of corticotropin-releasing hormone receptor gene (CRHR1) polymorphisms with adult depressive symptoms following early child abuse. The authors grounded this study in past work that identified hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis in major mood disorders. The authors concluded, "These data support the corticotropin-releasing hormone hypothesis of depression."^1(p190) The principal basis for this conclusion was that "Specific CRHR1 polymorphisms appeared to moderate the effect of child abuse on the risk for adult depressive symptoms."^1(p190) From the frequent use of alternative terms such as adult depression and major depressive disorder (MDD), it appears that the authors considered "depressive symptoms" a proxy for MDD in studying the first sample. There is no corticotropin-releasing hormone hypothesis of adult depressive symptoms. In . . . [Full Text of this Article]

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