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Kerry J. Ressler, MD, PhD; Rebekah G. Bradley, PhD; Joseph F. Cubells, MD, PhD; Elisabeth B. Binder, MD, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In reply

Dr Carroll raises issues with every aspect of our article "Influence of Child Abuse on Adult Depression: Moderation by the Corticotropin-Releasing Hormone Receptor Gene."¹ While some of the issues raised are reasonable, these were previously acknowledged in the limitations section of the article. We also believe (as supported later) that many of Dr Carroll's other comments are incorrect interpretations of the article or represent a skewed and biased perspective.

The letter begins with the statement that "There is no corticotropin-releasing hormone hypothesis of adult depressive symptoms," so we will address this issue first. Although Dr Carroll may not agree with the data supporting a role for corticotropin-releasing hormone (CRH) in mediating depression or depressive symptoms, there is an abundance of data. Using the combined search terms "corticotropin" and "depression" . . . [Full Text of this Article]

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