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Environmental Risk Factors and Attention-Deficit/Hyperactivity Disorder Symptoms
Christine M. Freitag, MD;
Jobst Meyer, PhD;
Andreas Reif, MD;
Michael Rösler;
K. Peter Lesch, MD;
Wolfgang Retz, MD
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The article by Laucht et al1 aims to elicit the independent and combined effects of the dopamine transporter gene (DAT1) 40–base pair (bp) variable number of tandem repeats (VNTR) polymorphism and psychosocial adversity on attention-deficit/hyperactivity disorder (ADHD) symptoms in 15-year-olds from a high-risk community sample. In addition, 4 further genetic variants in linkage disequilibrium with the DAT1 40-bp VNTR polymorphism were assessed.
Laucht et al reported an interaction of psychosocial adversity and the DAT1 40-bp VNTR and 30-bp VNTR polymorphisms as well as a haplotype of both variants with regard to at least 1 symptom of attention problems or hyperactivity-impulsivity. The interpretation of the results, however, requires some comment because of several limitations of the study.
1. Despite a thorough assessment by a structured psychiatric interview, the rates of . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED ARTICLE
Interacting Effects of the Dopamine Transporter Gene and Psychosocial Adversity on Attention-Deficit/Hyperactivity Disorder Symptoms Among 15-Year-Olds From a High-Risk Community Sample
Manfred Laucht, Markus H. Skowronek, Katja Becker, Martin H. Schmidt, Günter Esser, Thomas G. Schulze, and Marcella Rietschel
Arch Gen Psychiatry. 2007;64(5):585-590.
ABSTRACT
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RELATED LETTER
Environmental Risk Factors and Attention-Deficit/Hyperactivity Disorder Symptoms—Reply
Manfred Laucht, Markus H. Skowronek, Katja Becker, Martin H. Schmidt, Günter Esser, Thomas G. Schulze, and Marcella Rietschel
Arch Gen Psychiatry. 2008;65(3):357-358.
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