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John S. March, MD, MPH; for the TADS Team

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In reply

We thank Dr Antonuccio for his comments on the TADS. Dr Antonuccio makes the point that the TADS treatments eventually converge and that medications come with greater risks than CBT at all points. On this basis, he argues that CBT alone may represent the best balance of benefit and risk, with combined treatment (COMB) a distant second choice if speed of response is a major consideration. While there is wisdom in what he says, the data and clinical realities tell a somewhat more subtle and complex story.

With respect to acute treatment, effect sizes at week 12 derived from the odds ratio for the dichotomized Clinical Global Impression–Improvement score are 0.84 for COMB, 0.58 for fluoxetine therapy, and 0.20 for CBT indicating that COMB works best for depression. Looking at all possible outcomes, not just depression, COMB has a . . . [Full Text of this Article]

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