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Premature Recommendation of Corticotropin-Releasing Hormone as Screen for Postpartum Depression
Janet Rich-Edwards, ScD;
Michele Hacker, ScD;
Matthew Gillman, MD
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Yim and colleagues1 recently reported a positive association between maternal plasma levels of corticotropin-releasing hormone (CRH) at midpregnancy with risk of maternal depression at roughly 9 weeks postpartum. Their longitudinal cohort of 100 women yielded 16 cases of postpartum depression (PPD) at 9 weeks postpartum, as measured by the Edinburgh Postpartum Depression Scale with a threshold of 10 or greater to indicate probable minor depression. Yim and colleagues conclude that "midpregnancy pCRH [placental CRH] is a sensitive and specific early diagnostic test for PPD symptoms.’’1(p162)
In 2008, we published quite different results from a longitudinal analysis of CRH and perinatal depression in a demographically similar cohort, Project Viva.2 Among 600 participants, we detected 46 cases of PPD at 6 months postpartum, employing the more commonly used Edinburgh Postpartum Depression Scale threshold of 13 or greater to indicate probable major depression. For . . . [Full Text of this Article]
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Risk of Postpartum Depressive Symptoms With Elevated Corticotropin-Releasing Hormone in Human Pregnancy
Ilona S. Yim, Laura M. Glynn, Christine Dunkel Schetter, Calvin J. Hobel, Aleksandra Chicz-DeMet, and Curt A. Sandman
Arch Gen Psychiatry. 2009;66(2):162-169.
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