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Commentary on the Pittsburgh Study

Gerald L. Klerman, MD

Arch Gen Psychiatry. 1990;47(12):1158-1162.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The publication in this issue of the ARCHIVES of the report from the Pittsburgh (Pa) studies¹ on long-term treatment of recurrent unipolar major depression is important for a number of reasons.^2-4

The major findings are as follows: (1) high rate of recurrence in 1 year for untreated control groups; (2) clinically meaningful and statistically significant prevention of relapse

See also p 1093. and recurrence using both imipramine hydrochloride and interpersonal psychotherapy (IPT); (3) trend toward value of combined treatment; and (4) the value of high-dose imipramine hydrochloride (over 200 mg/d) and blood level determinations to enhance pharmacotherapy (Fig1).

These findings have an immediate practical application to the clinical management and treatment of this important group of patients. While there may be controversy regarding the natural history of major depression, particularly the kraepelinian concept of high rates of remission of the acute episode and favorable outcome over . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Psychiatry, Cornell University Medical College, New York, NY.

Footnotes
Accepted for publication September 11, 1990.

Reprint requests to the New York Hospital, Payne Whitney Clinic, 525 E 68th St, New York, NY 10021 (Dr Klerman).

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