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Ian Harvey, MSc; Maria Ron, PhD; George Du Boulay, FRCP; Robin Murray, DSc; Shon Lewis, MPhil
The Multiple Sclerosis Research NMR Unit National Hospital for Nervous Diseases Queen Square, London WC1N 3BG

Arch Gen Psychiatry. 1990;47(12):1172-1173.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In their recent article, Dupont et al stressed the importance of small focal white matter hyperintensities in bipolar disorder; these were absent in their control group but present in half of their patients. Although these focal abnormalities may reflect some disease, we wish to caution against the idea that they are not present in apparently healthy controls. As part of a magnetic resonance imaging study of schizophrenia, we collected data on 36 healthy controls and found similar small discrete abnormalities in seven people. These controls were matched to the patients by being taken from a similar parental social class, as well as being matched for age, sex, and race. All controls were younger than 50 years of age and had no history of neurologic or major psychiatric disorders, treated hypertension, systemic illness, or head injuries requiring hospital admission. The mean alcohol intake was less than 8 units . . . [Full Text PDF of this Article]

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